• DougGibson

@EndoCancer Cover stars!


Our working investigating the role of 27-hydroxycholesterol (27HC) in Endometrial Cancer is featured on the September cover of the journal Endocrine-Related Cancer.


The cover image depicts the expression of liver X receptor (LXR in green) and the proliferation marker Ki67 (red) across three grades of endometrial cancer: Well-, Moderate- and Poorly- differentiated. In the study, we found that 27HC could increase proliferation of cancer cells by activating LXR in well-differentiated cancers but in moderate or poorly differentiated cancers a drug that targeted LXR could decrease cancer cell proliferation (growth). To read more please see the open access paper available here or alternatively read the lay summary in the outreach section of this website.



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